Current treatments for multiple sclerosis (MS) are hindered by adherence
challenges linked to frequent systemic dosing regimens, which demand active
patient participation and often lead to suboptimal therapeutic outcomes.
Conventional disease-modifying therapies (DMTs) administered orally or via
injection, struggle to balance efficacy with patient quality of life, compounded by
risks of systemic toxicity and rapid drug clearance. Recent surveys underscore a
growing demand for implantable drug delivery systems (DDS) that minimize
dosing frequency, reduce patient burden, and enhance long-term compliance.
This dissertation addresses these unmet needs by developing an injectable
hydrogel platform based on aldehyde-functionalized hyaluronic acid (HAOX) and
chondroitin sulfate (CSOX), designed for localized, sustained delivery of antiinflammatory therapeutics. Central to this innovation is the immobilization of
polyelectrolyte complexes (PECs) within the covalently crosslinked hydrogel
matrix. Unlike conventional nanoparticle-based DDS, which rely on freely
diffusing carriers prone to burst release and instability, immobilized PECs exploit
electrostatic interactions between therapeutic agents (minocycline, MN;
Fluorescein isothiocyanate-modified synthetic Preimplantation Factor, FITCSPIF) and the anionic sulfate groups of CSOX. This strategy enhances drug
retention, reduces manufacturing complexity, and eliminates the need for costly
encapsulation processes.
| ISBN: | 978-80-7678-351-5 |
|---|
| EAN: | 9788076783515 |
|---|
| Počet stran |
42 stran |
| Datum vydání |
11. 09. 2025 |
| Pořadí vydání |
První |
| Jazyk |
anglický |
| Autor: |
Habibah Tutut Ummul |
| Nakladatelství |
Univerzita Tomáše Bati ve Zlíně |
| Tématická skupina |
999 - nezařazeno |
| Neprodejná publikace. Publikaci je možné poptávat zde: Volně dostupné na http://hdl.handle.net/10563/56897 |
|---|
Svaz českých knihkupců a nakladatelů