Living tissues are highly dynamic systems in which continuously changing
structural, mechanical, biochemical, and biological cues are intrinsically
combined within three-dimensional structures. Cells and tissue scaffolds
(extracellular matrix) play a critical and synergistic role, not only in the formation
of tissue architecture but also in the maintenance of its physiological function.
Therefore, both the role of cells and scaffolds are required to play integral roles
in the construction of reconstituted tissues. This is a dynamic and
multidisciplinary area of research. Models are finally applicable to tissue
engineering and regenerative medicine, disease modeling, and in vitro
experiments. Within the thesis, the main attention is paid to in vitro reconstituted
three-dimensional (3D) models of skin. Models should allow the reconstitution of
a skin architecture, and micro-environment, to enable the investigation of cellmatrix and cell-cell interactions between different cell types, and finally even
mimic the function and physiology of their in vivo tissue counterparts. The work
aims to clarify the preparation of the collagen layer and the subsequent provision
of an appropriate fibroblast-keratinocyte co-culture resulting in the functional
skin equivalent in vitro.
| ISBN: | 978-80-7678-363-8 |
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| EAN: | 9788076783638 |
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| Počet stran |
91 stran |
| Datum vydání |
03. 11. 2025 |
| Pořadí vydání |
První |
| Jazyk |
anglický |
| Vazba |
e-kniha - pdf |
| Autor: |
Kristýna Valášková |
| Nakladatelství |
Univerzita Tomáše Bati ve Zlíně |
| Tématická skupina |
999 - nezařazeno |
| Neprodejná publikace. Publikaci je možné poptávat zde: Volně dostupné na http://hdl.handle.net/10563/56902 |
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